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Symbol
Name
ID 		Pten
phosphatase and tensin homolog
MGI:109583
Phenotype annotations related to nervous system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Intracranial hemorrhage
Dilation of Virchow-Robin spaces
Hemimegalencephaly
Dysplastic gangliocytoma of the cerebellum
Meningioma
Speech apraxia
Intention tremor
Abnormality of speech or vocalization
Delayed speech and language development
Autistic behavior
Autism
Attention deficit hyperactivity disorder
Short attention span
Intellectual disability
Intellectual disability, mild
Global developmental delay
Motor delay
Delayed gross motor development
Seizure
Disease(s) Associated with PTEN
Bannayan-Riley-Ruvalcaba syndrome
macrocephaly-autism syndrome

Mouse Phenotypes
nervous system phenotype
seizures
tonic-clonic seizures
abnormal spike wave discharge
sporadic seizures
abnormal brain vasculature morphology
abnormal Bergmann glial cell differentiation
abnormal neuron differentiation
abnormal neuronal migration
abnormal neuronal precursor proliferation
open neural tube
kinked neural tube
wavy neural tube
increased solitary pulmonary neuroendocrine cell number
abnormal microglial cell physiology
abnormal response to CNS ischemic injury
increased neurofibrosarcoma incidence
abnormal nervous system morphology
abnormal enteric nervous system morphology
abnormal enteric ganglia morphology
abnormal enteric neuron morphology
abnormal brain morphology
abnormal brain development
abnormal cortical ventricular zone morphology
abnormal cerebellum development
abnormal cerebellar foliation
absent cerebellar foliation
abnormal cerebellum external granule cell layer morphology
abnormal olfactory bulb development
hydrocephaly
increased brain weight
increased brain size
abnormal brain white matter morphology
abnormal corpus callosum morphology
abnormal brainstem morphology
abnormal midbrain morphology
abnormal substantia nigra pars compacta morphology
abnormal substantia nigra pars reticulata morphology
abnormal striatum morphology
abnormal hippocampus morphology
abnormal hippocampus CA1 region morphology
abnormal dentate gyrus morphology
increased dentate gyrus size
abnormal hippocampal mossy fiber morphology
abnormal hippocampus layer morphology
abnormal hippocampus granule cell morphology
abnormal hippocampus pyramidal cell layer
abnormal hippocampus pyramidal cell morphology
decreased hippocampus pyramidal cell number
hippocampal neuron degeneration
abnormal cerebral hemisphere morphology
abnormal cerebral cortex pyramidal cell morphology
thickened cerebral cortex
abnormal olfactory bulb morphology
abnormal olfactory bulb mitral cell layer morphology
abnormal cerebellum morphology
abnormal cerebellar Purkinje cell layer
abnormal Bergmann glial cell morphology
ectopic Bergmann glia cells
abnormal Purkinje cell morphology
Purkinje cell degeneration
abnormal Purkinje cell dendrite morphology
decreased Purkinje cell number
ectopic Purkinje cell
abnormal cerebellar granule layer morphology
abnormal cerebellar granule cell morphology
ectopic cerebellar granule cells
thin cerebellar granule layer
abnormal cerebellar molecular layer
abnormal cerebellum vermis morphology
enlarged cerebellum
abnormal postnatal subventricular zone morphology
increased astrocyte number
astrocytosis
abnormal oligodendrocyte morphology
increased oligodendrocyte number
abnormal Schwann cell morphology
gliosis
abnormal innervation
abnormal dopaminergic neuron morphology
abnormal myelin sheath morphology
tomacula
abnormal dendrite morphology
increased dendritic spine density
increased neuronal precursor cell number
abnormal synapse morphology
abnormal synaptic vesicle number
ectopic neuron
neuron hypertrophy
abnormal optic nerve morphology
abnormal trigeminal nerve morphology
abnormal sciatic nerve morphology
abnormal nervous system physiology
abnormal astrocyte physiology
hypermyelination
reduced sensorimotor gating
abnormal synaptic transmission
abnormal CNS synaptic transmission
abnormal excitatory postsynaptic currents
abnormal excitatory postsynaptic potential
abnormal glutamate-mediated receptor currents
reduced long-term potentiation
abnormal miniature excitatory postsynaptic currents
increased miniature excitatory postsynaptic current amplitude
increased miniature excitatory postsynaptic current frequency
decreased prepulse inhibition
abnormal synaptic depression
Availability Mouse Genotype
Ptentm1.1Hwu/Ptentm1.1Hwu
Ptentm1.1Jaes/Ptentm1.1Jaes
Ptentm1.1Yxy/Ptentm1.1Yxy *
Ptentm1Engc/Ptentm1Engc
Ptentm1Mak/Ptentm1Mak
Ptentm1.1Hwu/Pten+
Ptentm1Engc/Pten+
Ptentm1Mak/Pten+
Ptentm1Rps/Pten+
Tg(Pten)1Srn/0
Ptentm1Hwu/Ptentm1Hwu
Tg(Gfap-cre)77.6Mvs/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Nes-cre)1Atp/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(GFAP-cre)25Mes/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Cnptm1(cre)Kan/Cnp+  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Plp1-cre/ERT2)1Ueli/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Slc6a3tm1.1(cre)Bkmn/Slc6a3+  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Tyr-cre)1Lru/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Camk2a-cre)T50Stl/0
Tg(Thy1-EGFP)MJrs/0  (conditional)
Ptentm1Mro/Ptentm1Mro
Tg(En2-cre)22Alj/0  (conditional)
Ptentm1Mro/Ptentm1Mro
Tg(Pcp2-cre)756Mro/0  (conditional)
Ptentm2.1Ppp/Ptentm2.1Ppp  (conditional)
Ptentm2.1Ppp/Ptentm2.1Ppp
Tg(Dhh-cre)1Mejr/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Gfap-cre)1Sbk/0  (conditional)
Ptentm2Mak/Ptentm2Mak  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Eno2-cre)39Jme/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Nes-cre/ERT2,-ALPP)1Sbk/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory